According to a study presented at the World Congress of Prague, the association between pioglitazone (or rosiglitazone) and acitretin would lead to an improvement in 64% of cases compared to 52% with acitretin alone.
The glitazones bind to a nuclear receptor called PPAR gamma (peroxisome proliferator-activated receptor gamma), which is mainly expressed in adipocytes and (to a lesser extent) in the liver and skeletal muscles.
According to the authors, the activation of PPAR-gamma may inhibit proliferation and induce cell differentiation.
(Source: Skin and Allergy News )
( More articles on PubMed )
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